Selected publications of CANCER-ID Partners

Circulating miRNA analysis for cancer diagnostics and therapy




Authors: Lukas Valihrach, Peter Androvic, Mikael Kubista



Circulating tumor cells in lung cancer are prognostic and predictive for worse tumor response in both targeted- and chemotherapy.

DOI: 10.21037/tlcr.2019.11.06



Release of circulating tumor cells during surgery for non-small cell lung cancer: are they what they appear to be?

Authors: Menno Tamminga, Sanne de Wit, Caroline Van De Wauwer, Hilda van den Bos, Joost F. Swennenhuis, Theo J. Klinkenberg, T Jeroen N Hiltermann, Kiki C Andree, Diana C.J. Spierings, Peter M Lansdorp, Anke van den Berg, Wim Timens, Leon WMM Terstappen and Harry JM Groen


Multicentric Evaluation of Circulating Plasma MicroRNA Extraction Technologies for the Development of Clinically Feasible Reverse Transcription Quantitative PCR and Next-Generation Sequencing Analytical Work Flows.

Clin Chem. 2019 Jun 24. pii: clinchem.2019.303271. doi: 10.1373/clinchem.2019.303271. [Epub ahead of print]


Authors: Kloten V, Neumann MHD, Di Pasquale F, Sprenger-Haussels M, Shaffer JM, Schlumpberger M, Herdean A, Betsou F, Ammerlaan W, Af Hällström T, Serkkola E, Forsman T, Lianidou E, Sjöback R, Kubista M, Bender S, Lampignano R, Krahn T, Schlange T; CANCER-ID consortium.


Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors

Journal for ImmunoTherapy of Cancer. (2019) 7:173

Authors: Menno Tamminga, Sanne de Wit, T. Jeroen N. Hiltermann, Wim Timens, Ed Schuuring, Leon W. M. M. Terstappen and Harry J. M. Groen


Clinical utility of circulating non-coding RNAs - an update.

Nat Rev Clin Oncol. 2018 Sep;15(9):541-563

Authors: Anfossi S, Babayan A, Pantel K, Calin GA


Clinical applications of the CellSearch platform in cancer patients.

Adv Drug Deliv Rev. 2018 Feb 1;125:102-121

Authors: Riethdorf S, O'Flaherty L, Hille C, Pantel K


Circulating Tumor Cells in Breast Cancer Patients Treated by Neoadjuvant Chemotherapy: A Meta-analysis.

J Natl Cancer Inst. 2018 Jun 1;110(6):560-567

Authors: Bidard FC, Klaus Pantel et al


Two-tailed RT-qPCR panel for quality control of circulating microRNA studies

Scientific Reports, Volume 9, Article number: 4255 (2019

Authors: Peter Androvic, Nataliya Romanyuk, Lucia Urdzikova-Machova, Eva Rohlova, Mikael Kubista, Lukas Valihrach


Liquid Biopsy Preservation Solutions for Standardized Analytical Workflows - Venous Whole Blood and Plasma

Current Pathobiology Reports, October 2018

Authors: Grölz D., Hauch S., Schlumpberger M., Guenther K., Voss T., Sprenger-Haussels M.  and Oelmüller U.


undefinedctDNA and CTCs in Liquid Biopsy - Current status and Where We Need to Progress

Computational and Structural Biotechnology Journal, June 2018

Authors: Neumann M H D, Bender S, Krahn T, Schlange T


Quantifying HER-2 expression on circulating tumor cells by ACCEPT

PLOS ONE, October 2017

Authors: Zeune L,  van Dalum G,  Decraene C,  Proudhon C,
Fehm T, Neubauer H, Rack B, Alunni-Fabbroni M, Terstappen L W M M, van Gils S A, Brune C


Biology and clinical significance of circulating tumor cell subpopulations in lung cancer

Tansl. Lung Canc. Res., August 2017

Authors: O’Flaherty L, Wikman H, Pantel K


Combining Contrast Invariant L1 Data Fidelities with Nonlinear Spectral Image Decomposition

Scale Space and Variational methods in Computer Vision, August 2017

Authors: Zeune L, van Gils S A, Terstappen L W M M, Brune C


Challenges and unanswered questions for the next decade of circulating tumour cell research in lung cancer

Tansl. Lung Canc. Res., August 2017

Authors: Mohan S, Chemi F, Brady G


Critical issues in the clinical application of liquid biopsy in nonsmall
cell lung cancer

J. of Thoracic Disease, July 2017

Authors:  Manicone M, Poggiana C, Facchinetti A, Zamarchi R


Molecular analysis of single circulating tumour cells following long-term storage of clinical samples

Mol. Oncol., July 2017

Authors: Mesquita B, Rothwell DG, Burt DJ, Chemi F, Fernandez-Gutierrez F, Slane-Tan D, Antonello J, Carter M, Carter L, Parry M, Franklin L, Marais R, Blackhall F, Dive C, Brady G.


A prospective examination of circulating tumor cell profiles in non-small-cell lung cancer molecular subgroups

Annals of Oncology, July 2017

Authors: Lindsay C.R. et al.


Circulating Tumor Cells with Aberrant ALK Copy Number Predict Progression-Free Survival during Crizotinib Treatmnet in ALK-Rearranged Non-Small Cell Lung Cancer Patients

Cancer Res, May 2017

Authors: Pailler E et al.


Two-tailed RT-qPCR: a novel method for highly accurate miRNA quantification

Nucleic Acids Res, July 2017

Authors: Androvich P, Vahlirach L, Elling J, Sjoeback R, Kubista M


Methods to determine limit of detection and limit of quantification in quantitative real-time PCR (qPCR)

Biomolecular Detection and Quantification, April 2017

Authors: Forootan A, Sjoeback R, Bjoerkman J, Sjoegreen B, Linz L, Kubista M


Integrating liquid biopsies into the management of cancer

Nature Reviews, March 2017

Authors: Siravegna G, Marsoni S, Siena S, Bardelli A


Circulating tumor cells: clinical validity and utility

Int. J. Clin. Oncol., February 2017

Authors: Cabel L, Proudhon C, Gortais H, Loirat D, Coussy F, Pierga JY, Bidard FC.


Circulating tumor cells and circulating tumor DNA: What surgical oncologists need to know?

Eur J Surg Oncol., January 2017

Authors: Cabel L, Proudhon C, Mariani P, Tzanis D, Beinse G, Bieche I, Pierga JY, Bidard FC.


Improved detection of circulating tumor cells in non-metastatic high-risk prostate cancer patients

Sci. Rep., December 2016

Authors: Kuske a et al.


Epithelial-mesenchymal plasticity in circulating tumor cells

J. Mol. Med., December 2016

Authors: Francart ME, Lambert J, Vanwynsberghe AM, Thompson EW, Bourcy M, Polette M, Gilles C.


Blood-Based Analysis of Circulating Cell-Free DNA and Tumor Cells for Early Cancer Detection

PLoS Med., December 2016

Authors: Pantel K


Improving the CellSearch® system

Expert Review of Molecular Diagnostics, October 2016

Authors: Swennenhuis JF, van Dalum G, Zeune LL, Terstappen LWMM


Zirkulierende Tumorzellen: Ist die Metastasierung bald vorhersagbar?

Perspektiven der Onkologie, September 2016

Authors: Gorges TM and Pantel K


Accession of Tumor Heterogeneity by Multiplex Transcriptome Profiling of Single Circulating Tumor Cells

Cancer Diagnostics, September 2016

Authors: Gorges TM, Kuske A, Röck K, Mauermann O, Müller V, Peine S, Verpoort K, Novosadova V, Kubista M, Riethdorf S, Pantel K


Inferring expressed genes by whole-genome sequencing of plasma DNA

Nature Genetics, August 2016

Authors: Peter Ulz et al.


Capture of Tumor cells on Anti-EpCam-funcionalized Poly (acrylic acid)-coated surfaces

ACS Appl Mater Interfaces, August 2016

Authors: Andrée KC, Barradas AMC, Nguyen AT, Mentink A, Stojanovic I, Baggerman J, van Dalum J, van Rijn CJM, and Terstappen LWMM


Frequent detection of PIK3CA mutations in single circulating tumor cells of patients suffering from HER2-negative metastatic breast cancer

Mol Oncol., July 2016

Authors: Gasch C, Oldopp T, Mauermann O,Gorges TM, Andreas A, Coith C, Mueller V, Fehm T, Janni W, Pantel K, Riehtdorf S


Characterization of different subpopulations in non-small cell lung cancer

Sci Rep., June 2016

Authors: Hanssen et al.


Improved dectection of circulating tumor cells in metastatic colorectal cancer by the combination of the CellSearch® System and the AdnaTest®

PLOS ONE, May 2016

Authors: Gorges TM, Stein A, Quidde J, Hauch S, Röck K, Riehtdorf S, Joosse S, Pantel K


Multiscale Segmentation via Bregman Distances and Nonlinear Spectral Analysis

Mol Oncol, April 2016

Authors: Zeune L, van Dalum G, Terstappen LWMM, van Gils SA, Brune C

Challenges in circulating tumor cell detection by the CellSearch System

Mol Oncol, March 2016

Authors: Andree KC, van Dalum G, Terstappen LW.


Blood circulation tumor DNA for non-invasive genotyping of colon cancer patients

Molecular Oncology, December 2015

Authors: Siravegna G, Bardelli A


Heterogeneous PSMA expression on circulating tumor cells - a potential basis for stratification and monitoring of PSMA-directed therpies on prostate cancer

Oncotarget, April 2016

Authors: Gorges TM, Riethdorf S, von AHsen O, Nastaly P, Röck K, Boede M, Peine S, Kuske A, Schmid E, Kneip C, König F, Rudolph M, Pantel K


Intraindividual Temporal miRNA Variability in Serum, Plasma, and White Blood Cell Subpopulations

Biopreserv Biobank, April 2016

Authors: Ammerlaan W, Betsou F


MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations

Science Translational Medicine, February 2016

Authors: Arena S, Siravegna G, Mussolin B, Kearns JD, Wolf B, Misale S, Lazzari L, Bertotti A, Trusolino L, Adjei A, Montagut C, Nicolantonio F, Nering R, Bardelli A


Potential of circulating tumor cells as blood-based biomarkers in cancer liquid-biopsy


Pharmacogenomics, January 2016

Authors: Schlange T and Pantel K


Enumeration and molecular characterization of tumor cells in lung cancer patients using a novel in vivo device for capturing circulating tumor cells.


Clin Cancer Res., December 2015

Authors: Gorges TM, Penkalla N, Schalk T, Joosse S, Riethdorf S, Tucholski J, Lucke K, Wikman H, Jackson SM, Brychter N, von Ahsen O, Schumann C, Krahn T, Pantel K. 


A novel microfluidic platform for size and deformability based separation and the subsequent molecular characterization of viable circulating tumor cells.


Int J Cancer, January 2016

Authors: Hvichia GE, Parveen Z, Wagner C, Janning M, Quidde J, Stein A, Müller V, Loges S, Neves RP, Stoecklein NH, Wikman H, Riethdorf S, Pantel K, Gorges TM


Clinical evaluation of a novel microfluidic device for epitope-independent enrichment of circulating tumour cells in patients with small cell lung cancer.


Analyst, January 2016

Authors: Chudziak J, Burt DJ, Mohan S, Rothwell DG, Mesquita B, Antonello J, Dalby S, Ayub M, Priest L, Carter L, Krebs MG, Blackhall F, Dive C, Brady G.


Challenges for CTC-based liquid biopsies: low CTC frequency and diagnostic leukapheresis as a potential solution


Expert Review of Molecular Diagnostics, December 2015

Authors: Stoecklein N, Fischer J, Niederacher D, Terstappem LWMM

Genetic profiling of tumours using both circulating free DNA and circulating tumour cells isolated from the same preserved whole blood sample.


Molecular Oncology, November 2015

Authors:Rothwell DG, Smith N, Morris D, Leong HS, Li Y, Hollebecque A, Ayub M, Carter L, Antonello J, Franklin L, Miller C, Blackhall F, Dive C, Brady G.


Industry-academia collaborations for biomarkers


Nature Reviews, October 2015

Authors: Khusru Asadullah, Andreas Busch, Matthias Gottwald, Petra Teinke and Lilla Landeck

Characterization of DNA Methylation in Circulating Tumor Cells


genes, October 2015

Authors: Constantin F. Pixberg, Wolfgang A. Schulz, Nikolas H. Stoecklein and Rui P. L. Neves


Data Normalization Strategies for MicroRNA Quantification


Clin Chem, September 2015

Authors: H. Schwarzenbach, A. Machado da Silva, G. Calin and K. Pantel


CCR 20th Anniversary Commentary: Paving the Way for Circulating Tumor Cells


Clin Cancer Res, June 2015

Authors: W. Jeffrey Allard and Leon W.M.M. Terstappen


The Biology of Circulating Tumor Cells


Oncogene, June 2015

Authors: K. Pantel and M. Speicher

CANCER-ID Consortium

CANCER-ID consortium

CANCER-ID Workpackages



News from the European Comission

What's new in Health and Life Sciences? Click here for news from the European Commission.


EU logo
imi Logo
efpia Logo

News Section

Vestec by Prague, Czech Republic

5th - 6th of June, 2019

... Read more

Social Media

LinkedIn Cancer-ID