The Intergrated BioBank of Luxembourg (IBBL) is an autonomous not-for-profit institute dedicated to supporting biomedical research for the benefit of patients. IBBL is an integrated research infrastructure offering bioservices, including the collection, processing, analysis and storage of biological samples and associated data. In addition, IBBL carries out research to optimise biospecimen processing and certify biospecimen quality. IBBL is ISO 9001:2015 certified and ISO 17025:2005 accredited, and its quality management system is conceived to be compliant with NF S96-900:2011 and ISO 17043:2010. IBBL's mission is to provide biospecimen related services and a biobanking infrastructure for applied medical research. IBBL's vision is to be an international centre of excellence in biobanking and a valued partner in developing better healthcare solutions. IBBL is an autonomous institute, organised within the Luxembourg Institute of Health (LIH). As part of this consortium, IBBL contributes to a number of activities, including: definition of criteria for the analysis of circulating nucleic acids; development of simple clinical protocols ensuring sample integrity and permitting analyses after a prolonged storage at room temperature; validation of methods for CTC identification and single-cell isolation; development of a series of SOPs; and support in the organisation of ring trials and preparation of quality control materials.